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Lab Automated Tissue Homogenizer
Introduction to the Tissue Homogenizer
In the realm of scientific research, where precision and efficiency are crucial, Tissue Grinder from Shanghai Jingxin® emerges as a cutting-edge solution. This state-of-the-art grinder is designed to enhance your laboratory capabilities, offering a blend of advanced technology and user-centric features. Whether you’re working with DNA, RNA, or proteins, we promises unparalleled performance and versatility.Enhanced Performance and Design
Tissue Grinder homogenizers stands out with its new-generation motor and robust anti-corrosion materials. These updates not only boost its performance but also enhance its aesthetic appeal. Key enhancements include:- High-Frequency Oscillation: The grinder operates with high-frequency oscillation, allowing for rapid and thorough processing of samples. This ensures efficient grinding, pulverization, mixing, and cell breakage in a fraction of the time.
- Advanced Motion Axis: The improved motion axis contributes to the precision of the grinding process, providing consistent results and enhancing the overall durability of the grinder.
- Sleek Design: The grinder’s modern and attractive design is complemented by its functional enhancements, making it a valuable addition to any laboratory.
Versatile Applications
Tissue Grinder is designed to handle a wide range of sample types and applications, making it a versatile tool for various research needs:- Plant Tissues: The grinder efficiently processes plant tissues, including roots, stems, leaves, flowers, fruits, and seeds. This versatility supports research in botany, agriculture, and related fields.
- Animal Tissues: Ideal for grinding animal tissues such as brain, heart, lung, stomach, liver, thymus, kidney, intestine, lymph node, muscle, and bone. It is useful for studies in veterinary science and biomedical research.
- Microorganisms: Suitable for grinding fungi, bacteria, yeast, and other microorganisms. This feature is essential for microbiological studies and genetic research.
- Food and Medicine: The grinder can process various food and medicinal samples, aiding in nutritional studies, pharmaceutical research, and quality control.
- Volatile Samples: Handle volatile materials such as coal, oil shale, wax products, and others. This capability supports environmental studies and material science research.
- Plastics and Polymers: The grinder is capable of processing plastics and polymers, including PE, PS, textiles, resins, and more, making it useful for materials science and recycling studies.
Key Features and Performance Indicators
Tissue Grinder offers a range of features tailored to meet diverse laboratory needs:- High Throughput: Capable of processing up to 2×24, 2×48, or 4×96 samples per minute, the grinder ensures high efficiency and time-saving. The maximum oscillation speed of 70 Hz (2100 times/minute) enables rapid and effective sample processing.
- Precision Grinding: The grinder achieves particle sizes as fine as ~5 µm. Grinding balls are available in various diameters (0.1-30 mm) and materials, including stainless steel, chrome steel, zirconium oxide, tungsten carbide, and quartz sand.
- Flexible Grinding Modes: Choose from wet grinding, dry grinding, or low-temperature grinding to suit your specific needs. The grinder’s ability to perform at different temperatures enhances its versatility.
- User-Friendly Interface: Equipped with a key broken code screen display, the grinder offers easy operation and high stability. Users can set grinding time, rotor vibration frequency, and other parameters through the built-in program controller.
Superior Performance Characteristics
The Tissuelyser® excels in several critical areas, ensuring top-notch performance and reliability:- High Efficiency: The grinder’s ability to handle a large number of samples with minimal batch variation ensures high specific activity of extracted proteins and longer nucleic acid fragments.
- No Cross-Contamination: The fully enclosed sample tubes and the use of disposable centrifuge tubes and beads prevent cross-contamination, maintaining sample integrity.
- Ease of Use: The built-in program controller and intuitive interface simplify operation, making the grinder accessible to users of varying experience levels.
- Low Noise Operation: Operating at less than 55 dB, the grinder’s noise level is minimal, allowing it to be used in shared laboratory environments without disturbing other experiments or instruments.
- Convenient Low-Temperature Operation: For low-temperature grinding, samples can be quickly transferred from liquid nitrogen to the grinder, saving time and minimizing liquid nitrogen usage.
Precautions and Maintenance
To ensure the optimal performance and longevity of your Tissuelyser® Tissue Grinder, follow these guidelines:- Placement: Position the grinder in a dry, well-ventilated environment to prevent damage and ensure proper function.
- Voltage Requirements: The grinder operates on a 220V power supply. Ensure that your laboratory’s electrical setup meets this requirement.
- Safety Measures: When using liquid nitrogen, take appropriate protective measures to avoid frostbite. Handle the material with care and follow safety protocols.
- Adapter Maintenance: Fix the adapter securely before starting the grinding process. Ensure the vertical positioning screw is tightened and the safety lock is fastened.
- Sample Placement: Place samples symmetrically in the grinder to ensure balanced force distribution during processing.
- Post-Operation Care: After grinding, turn off the power and return the safety lock to its place. Regularly clean the adapter to prevent residual drugs or samples from causing corrosion.
About Our Factory
Established in 2008, our company has always been aiming at providing high quality laboratory homogenizers at competitive prices. We have a modern production workshop and warehouse of 5500 square meters, with an average daily production capacity of more than 300 units.
Our products include: Enhanced Multi-Sample Tissue Mill, Enhanced Fully Automated Sample, Enhanced Freeze Grinder, Multi-Sample Tissue Mill, Fully Automated Sample Rapid Grinder, Cryogenic Tissue Mill.
What We Do
As the world’s leading supplier of tissue mills, our factory is passionate about grinding technology. We offer a wide range of products including handheld tissue mills, frozen tissue grinders, high throughput tissue grinding machines, bead grinders, soil grinding machines, and other types of grinding equipment to our customers around the globe.
Our grinder products are widely used for grinding and breaking of various plant tissues, animal tissues, fungi and bacteria, plastics, polymers, food products, pharmaceutical tablets, hair, bones, chlorophyll A, soil and other samples.
Frequently Asked Question
Popular questions about soil grinding, hair grinding, plant tissue grinding and animal tissue grinding.
Tissue grinders are essential tools in laboratories for breaking down and homogenizing biological tissues to prepare them for further analysis. These devices are used to disrupt the cells within a sample, releasing their internal components like proteins, nucleic acids, and other biomolecules. This homogenization process is critical in various studies, including molecular biology, biochemistry, and histology, where precise tissue breakdown is required to extract cellular components or prepare tissues for further examination under a microscope. By creating a uniform suspension of tissue, grinders ensure consistent and reproducible results in experiments, which is crucial for maintaining the integrity and accuracy of scientific research.
In practice, tissue grinders are often used when researchers need to isolate specific cells or components, such as DNA, RNA, or enzymes, from a tissue sample. For example, in cancer research, tissue grinders can be employed to break down tumor tissues into a homogeneous solution to study cellular structures, gene expression, or protein function. Similarly, in pharmacological studies, they help in preparing tissue samples to assess the effects of various drugs at a cellular level. Thus, tissue grinders play a vital role in enabling a deeper understanding of biological processes and advancing various fields of scientific inquiry.
While both grinders and homogenizers are used in laboratories to process biological samples, they serve slightly different purposes and employ distinct mechanisms. A grinder is typically designed to physically break down larger pieces of tissue or plant material into smaller, more manageable fragments. This is often done through mechanical force, such as grinding or crushing with a pestle against a mortar, or using a blade to shear the tissue. Grinders are particularly useful when the goal is to create a coarse mixture or when working with relatively tough or fibrous materials that require significant mechanical disruption.
On the other hand, a homogenizer is used to achieve a much finer, uniform suspension or solution of cellular components. Homogenizers work by applying intense mechanical forces, such as high-pressure, rapid agitation, or ultrasonication, to thoroughly disrupt cell membranes and release intracellular contents into the surrounding medium. They are designed to create a consistent mixture where all components are evenly distributed, which is essential for applications like protein extraction, cell fractionation, or preparing samples for molecular analysis. In summary, while grinders are used for coarse breakdown of materials, homogenizers are designed to achieve a more thorough and uniform blending of the sample.
While both homogenizers and sonicators are used to break down and mix biological samples in the laboratory, they are not the same and operate on different principles. A homogenizer is a general term for any device that creates a uniform mixture by mechanically disrupting cells or tissues. This disruption can be achieved through various methods, such as high-pressure forces, bead beating, or mechanical stirring. The primary goal of a homogenizer is to ensure that all components within a sample are evenly distributed, making it suitable for applications like protein extraction, cell lysis, or preparing suspensions for analysis.
A sonicator, on the other hand, is a specific type of homogenizer that uses ultrasonic waves to achieve cell disruption and homogenization. It works by generating high-frequency sound waves that create microscopic bubbles in the liquid sample. These bubbles rapidly expand and collapse, a process known as cavitation, which generates intense mechanical forces that break apart cells and tissues. Sonicators are particularly useful for disrupting tough cell walls, like those found in bacteria or yeast, and for applications where a very fine level of homogenization is required.
In summary, while all sonicators are homogenizers, not all homogenizers are sonicators. Sonicators use ultrasonic energy to achieve homogenization, while other types of homogenizers may use different mechanical forces. The choice between a sonicator and another type of homogenizer depends on the specific requirements of the experiment, such as the type of sample, the level of cell disruption needed, and the desired consistency of the final mixture.
Homogenizing tissue for RNA extraction is a critical step to ensure the isolation of high-quality RNA, which is essential for various downstream applications like qPCR, RNA sequencing, and gene expression analysis. The goal of homogenization in this context is to break down the tissue structure and release the cellular RNA while minimizing degradation by RNases—enzymes that can quickly degrade RNA. To achieve this, the process must be carried out swiftly and under cold conditions to preserve RNA integrity.
To homogenize tissue for RNA extraction, start by placing the tissue sample in a cold, RNase-free container with a suitable lysis buffer, such as TRIzol or another guanidinium thiocyanate-based solution, which helps to denature proteins, inactivate RNases, and protect the RNA. Depending on the type of tissue, mechanical disruption can be performed using a homogenizer, such as a bead mill, rotor-stator homogenizer, or a mortar and pestle. Ensure that the homogenizer or beads are thoroughly cleaned and decontaminated to prevent RNase contamination. It’s essential to work quickly and keep the sample cold throughout the process to prevent RNA degradation.
Once homogenization is complete, you should have a uniform lysate free of visible tissue fragments. This lysate can then be further processed according to the RNA extraction protocol, typically involving steps like phase separation, RNA precipitation, washing, and resuspension. By thoroughly homogenizing the tissue and efficiently lysing the cells, you can maximize RNA yield and purity, leading to more reliable and accurate results in subsequent analyses.
Tissue homogenization is the process of mechanically breaking down tissue into a uniform mixture, or homogenate, to release cellular components such as proteins, DNA, RNA, and other biomolecules. This step is crucial in many biological and biochemical studies, as it allows researchers to obtain a consistent sample where all cells are evenly disrupted and their contents are accessible for further analysis. Homogenization can involve various methods, including mechanical grinding, bead beating, or ultrasonication, depending on the type and toughness of the tissue, as well as the specific requirements of the experiment.
The primary goal of tissue homogenization is to ensure that the sample is evenly processed, creating a solution where every part of the tissue has been broken down to the same extent. This uniformity is essential for obtaining reliable and reproducible results, whether isolating nucleic acids for genetic studies, extracting proteins for enzyme assays, or preparing samples for microscopy. The effectiveness of tissue homogenization also depends on the conditions under which it is performed, such as temperature and the choice of buffer, to prevent degradation of sensitive molecules like RNA or proteins.
By achieving a thorough and consistent breakdown of tissues, researchers can ensure that their samples are suitable for subsequent experimental steps. This foundational step in many laboratory workflows directly impacts the accuracy and reliability of downstream applications, such as gene expression analysis, protein quantification, or cell characterization.
A homogenizer is a key laboratory instrument used to break down and blend biological samples into a uniform mixture, or homogenate, to ensure consistent and efficient analysis. The primary purpose of a homogenizer is to disrupt cells, tissues, or other materials to release their internal contents—such as proteins, DNA, RNA, lipids, and other biomolecules—into a solution. This process is essential for experiments that require even distribution of these components, as it ensures that every part of the sample is equally represented, which is crucial for obtaining reliable and reproducible data.
Homogenizers are particularly valuable in applications such as molecular biology, microbiology, and pharmacology. For example, in molecular biology, a homogenizer might be used to extract RNA from tissue samples, ensuring that the RNA is released uniformly from all cells for accurate gene expression analysis. In microbiology, they can be used to break down bacterial or yeast cell walls to isolate intracellular contents for further study. In pharmacology, homogenizers help prepare tissue samples to test the effects of drugs at the cellular level. Overall, a homogenizer is vital for preparing samples in a wide range of scientific studies, enabling researchers to obtain the high-quality, homogeneous samples necessary for precise and effective research.
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You can customize any type of tissue grinder from our factory to meet your requirements.